Non-toxic suprarenal preparation.



GEORG ZUELZER, OF BERLIN-CHARLOTTENBURG, GERMANY.

NON-TOXIC SUPRARENAL PREPARATION.

'No Drawing.

" To all whom it may concern:

- tor of medicine, citizen of the German Emished or entirely removed. This action seems to be due to a chemical alteration of the su Be it known that I, GEoRG ZIIELZER, doc

'pire, residing at Berlin-Charlottenburg,

Kingdom of Prussia, German Empire, have invented anew and useful Improvement in Non Toxic suprarenal Preparations, of which the following is a specification.

It has been found that suprarenal preparations influence both the pressure of the blood and the metabolism of sugar and that these actions are related so that -if-it were possible to lessen or increase one action the other would be correspondingly modified. 3

According to this invention I add to such suprarenal preparations extracts or juices obtained by compressing a suitable abdominal organ, .as for instance the pancreas, the spleen, or liver. The juice of pancreas gives the best results. Such addition paralyses the mobilization of sugar, due to the said preparations and simultaneously lessens their typical action of increasing the pressure of the blood while the addition produces a peculiar unknown action on the heart which corresponds to that of digitalis. The heart will now beat slowly and powerfully while without such addition the heart beat would be considerably accelerated and the pulse diminished. The addition of such bodies to suprarenal preparations thus renders them to a certain degree non-toxic in so far as the injurious or quasi toxic action of suprarenal preparations, consisting in suddenly raising the blood pressure, and in the mobilization of sugar, is greatly diminprarenal preparations as appears from the fact that the addition of ammonium sulfate to such preparations or to pancreas or other extract which is free-from albuminous matter produces no precipitate, while after the addition of such extract to such suprarenal preparations a precipitate is formed by the addition of ammonium sulfate. ple there is'added to a solution of 0.8 millirams of a suprarenal preparation'(whose injection into a rabbit produces the above Specification of Letters Patent.

For exar'n- 1 Patented Jan. 9,1912.

Application filed July 7, 1910. .Serial No. 570,736.

mentioned unfavorable action upon the heart.

as Well as an enormousrise in the pressure of the blood and a large precipitation'of sugar in the urine) 2 cubic centimeters of a juice obtained by compression of the pan-v creas (or another suitable organ-such asthe spleen or liver) and allow this substance to react for at least one hour. If 't-he' supra; renal preparation s0 treated be again injector. alarge rise of ,the pressure of the blood and the heart reacts in the favorable manner above mentioned.

x I claim as my invention 1. The herein described suprarenal preparation which contains the blood-pressure ed no precipitation of sugar then takes place raising and sugar-mobilizing suprarenal substance and the extract from a suitable abdominal organ, such preparation, if injected, operating with a modified mobilization of sugar and diminished raising of the blood pressure,dsubstantially as set forth.

2. The herein described suprarenal prep-"" I aration which'contains the blood-pressure raising and sugar-mobilizing suprarenal substance and as set forth.

3. The herein described process of manufacturing suprarenal. preparations which consists in mixing the blood-pressure-raising and sugar-mobilizing suprarenal substance With the extract from'a suitable abdominal organ which neutralizes the blood-pressureraising and sugar-mobilizing eflectof the suprarenal substance, substantiallyv asset forth.

4. The herein describedprocess of manufacturing suprarenal preparations. which consists in mixing the blood-pressure-raising and sugar-mobilizing suprarenal substance pancreas extract, substantially as set with forth.

In testimony whereof I hereunto setmy presence of-two subscribing GEORG ZUELZER.

signature in the witnesses.

Witnesses:

-HENRY HASPER, WoLDEMAn HAUPT.

pancreas extract, substantially y 5 

